Spherical nucleic acids for precision medicine
نویسندگان
چکیده
منابع مشابه
Spherical nucleic acids for precision medicine
With the advent of functional cancer genomics, precision medicine has begun to enter clinical practice. Therapeutic regimens are informed by the tumor’s genotype to specifically target critical genetic aberrations that are the driving forces of disease progression. While several targeted small molecule inhibitors and biotherapeutic antibodies have been FDA-approved, in particular those targetin...
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A novel class of metal-free spherical nucleic acid nanostructures was synthesized from readily available starting components. These particles consist of 30 nm liposomal cores, composed of an FDA-approved 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) lipid monomer. The surface of the liposomes was functionalized with DNA strands modified with a tocopherol tail that intercalates into the phosph...
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Immunomodulatory nucleic acids have extraordinary promise for treating disease, yet clinical progress has been limited by a lack of tools to safely increase activity in patients. Immunomodulatory nucleic acids act by agonizing or antagonizing endosomal toll-like receptors (TLR3, TLR7/8, and TLR9), proteins involved in innate immune signaling. Immunomodulatory spherical nucleic acids (SNAs) that...
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Spherical nucleic acids (SNAs) represent an emerging class of nanoparticle-based therapeutics. SNAs consist of densely functionalized and highly oriented oligonucleotides on the surface of a nanoparticle which can either be inorganic (such as gold or platinum) or hollow (such as liposomal or silica-based). The spherical architecture of the oligonucleotide shell confers unique advantages over tr...
متن کاملDesign Considerations for RNA Spherical Nucleic Acids (SNAs)
Ribonucleic acids (RNAs) are key components in many cellular processes such as cell division, differentiation, growth, aging, and death. RNA spherical nucleic acids (RNA-SNAs), which consist of dense shells of double-stranded RNA on nanoparticle surfaces, are powerful and promising therapeutic modalities because they confer advantages over linear RNA such as high cellular uptake and enhanced st...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2013
ISSN: 1949-2553
DOI: 10.18632/oncotarget.1757